Prof. Daniele Manfredini received his DDS from the University of Pisa, Italy, in 1999, an MSc in Occlusion and Craniomandibular Disorders in 2001 from the same University, a PhD in Dentistry from the ACTA Amsterdam, The Netherlands, and a Post-Graduation Specialty in Orthodontics from the University of Ferrara, Italy. He achieved the Diplomate Status from the American Board of Orofacial Pain in 2021.

From 2006 to 2016, Daniele Manfredini served as Assistant Professor at the TMD Clinic, Department of Maxillofacial Surgery, University of Padova, Italy.

Since 2017, Daniele Manfredini has served as Professor at the School of Dentistry, Department of Medical Biotechnologies, University of Siena, Italy, where he holds teachings in Oral Physiology and Clinical Gnathology. He is currently the Director of the Orofacial Pain Unit as well as the Coordinator of the Postgraduate Programs in Orofacial Pain and Temporomandibular Disorders.

Daniele Manfredini has authored more than 350 papers in the field of bruxism, orofacial pain, and temporomandibular disorders in journals indexed in the Medline database (Scopus H-index=71). Since the first release of world rankings in 2013, he has been ranked in the top three experts in TMD and bruxism by the agency ExpertScape. He has been listed in the top ten researchers in the whole of dentistry by the Stanford University ratings in 2025.

He is Member and Coordinator of the Bruxism Consensus Panel within the International Association for Dental Research, which works on the updated definition and classification strategies for bruxism and for which he currently serves on the INfORM Board of Directors.

He is the co-Founder and Vice-President of the International Association for Orofacial Pain (IAOFP).

Since January 1st, 2024, Daniele Manfredini has been Editor-in-Chief of CRANIO: The Journal of Craniomandibular and Sleep Practice, official journal of the American Academy of Orofacial Pain and sister academies.